Background: atrazine is widely used organophosphate herbicide that adversely affects the structure of the thyroid gland. So this work was performed to study the possible ameliorative effects of ginger extract against toxic effects of atrazine on the thyroid gland of albino rats. Methods: Forty male adult albino rats were subdivided into four equal subgroups each contain 10 rats. Group I: each rat was given 5ml of water once daily orally for thirty days. Group II: each rat received (750 mg/kg body weight) of ginger extract by oral gavage, once daily for thirty days. Group III: each rat received (100 mg/kg body weight) of atrazine by oral gavage for thirty days. Group IV: each rat received (100 mg/kg body weight) atrazine and 750mg/kg body weight of ginger aqueous extract by oral gavage once per day for thirty days. Results: Atrazine caused structural damage of thyroid gland in the form of disruption of the shape of the follicles. The colloid was vacuolated, increased collagen deposition, decreased amount of colloid and increased caspase-3 intensity immunoreaction with decreased serum levels of T3&T4 and increased serum level of TSH also there was increased level of MDA in thyroid tissue. On the otherwise the concurrent administration of ginger extract aqueous solution with atrazine cause improvement in the previous changes that caused by atrazine only. Conclusions: Ginger extract administration with atrazine could ameliorate the toxic effects of atrazine on thyroid gland.