Introduction: In patients with obstructive sleep apnea (OSA), the retropalatal area (RP) is usually considered the most common collapsible site of the upper airway (UA). The anterior palatoplasty (AP) technique was described by Pang and colleagues. The original AP had been performed only for patients with snoring and mild OSA Objective: This study tried to assess the surgical outcome of anterolateral advancement palatoplasty (ALP) with simultaneous tonsillectomy for the treatment of retropalatal obstruction in selected cases of obstructive sleep apnea (OSA). Materials and Methods: In this clinical trial, 22 adult OSA patients having predominant retropalatal collapse were managed by ALP and tonsillectomy.Thirteen patients had positional OSA (PP) and 9 patients had non-positional (NPP). ALP entailed the stripping of a horizontal trapezoid area of mucosa/submucosa of the soft palate and suturing with one central simple suture and two paramedian sutures made as an anterolateral parallelogram. Uvula was not jeopardized and no lateral mucosal cuts were made. Results: Postoperative data of the study group showed high signifcant improvement (p0.05) as regards LO2, ESS and VAS-s. Postoperative means of AHI in supine position showed a signifcant diference (p=0.03). Upon comparison of means of ODI and T90% of PP and NPP, a highly signifcant diference was reported in both pre- and postoperative comparison (<0.001). Conclusion: Anterolateral advancement palatoplasty seems to be an easy, efective and low-cost procedure. More favorable outcomes were reported among positional-dependent subjects. The procedure could be employed in multilevel, single-stage surgery for patients with OSA