Background: Carbon monoxide (CO) poisoning is one of the most common fatal poisoning worldwide. CO poisoning is known to have several complications and high fatality rate. Cardiac dysfunction including arrhythmias and myocardial ischemia have often been reported in CO poisoning; scattered punctiform hemorrhages throughout the heart have been documented in autopsy samples. Whilst it is one of the most common lethal poisonings, neurological or psychiatric sequelae occurs in up to 67% of survivors. This suggests that CO is implicated in neuronal death, or loss of function of the cells in the central nervous system. Approximately half of those who survive severe CO poisoning develop delayed neurological sequelae (DNS) after a latency period of 2–40 days, with varied clinical manifestations, persistent neuropsychological effects, and no guarantee of complete recovery. However, they are potentially preventable if they are early recognized and adequately treated.