The research focused on how the Qur'an and Sunnah deal with epidemics and their effects, and came within the framework of answering questions that we need as Muslims: How did Islam deal with epidemics? How did the Holy Qur'an, as the primary tool for action, deal with epidemics in all their forms? How did the Sunnah, as the secondary tool for action, deal with epidemics? Did epidemics have jurisprudential, social, and economic effects? How did Islam deal with them? What is the role of modern preventive medicine in dealing with epidemics? The title of the research, “The Qur'an and Sunnah on Epidemics and Their Effects,” refers to the unique statements of the Qur'an and Sunnah on dealing with epidemics and determining the role of preventive medicine in dealing with them . The research aims to identify responses in the Qur'anic and prophetic texts that include preventive measures and precautions in light of these texts, and to achieve the objectives of Islamic law, such as preserving life, removing hardship, promoting the public interest, and preventing harm . Among its most important findings and recommendations are: learning from ancient and modern Islamic history that nations are exposed to epidemics and plagues, and that epidemics do not afflict the inferior without afflicting the superior; rather, it has been proven that epidemics afflicted the best of the nation, the noble Companions, may Allah be pleased with them . This has had several consequences, including: the need for medical treatment, death as a result of the epidemic, economic consequences, jurisprudential consequences, and social consequences . Preventive medicine played a very important role, such as purification, moderation in food, drink, sleep, and sexual intercourse, attention to physical exercise, adherence to the etiquette of sneezing and yawning, quarantine, and the necessity of taking medically prescribed vaccines. One of the most important recommendations is to compile a jurisprudential and ethical code specific to epidemics in order to link the two in a new way. Keywords: epidemics, the Holy Qur'an, the Sunnah, preventive medicine . Translated with DeepL.com (free version