RVG-exosome-mediated delivery of GDNF mRNA: A non-invasive breakthrough for Parkinson’s disease

Faculty Pharmacy Year: 2025
Type of Publication: ZU Hosted Pages:
Authors:
Journal: Medical Hypotheses Elsevier Ltd. Volume:
Keywords : RVG-exosome-mediated delivery , GDNF mRNA: , non-invasive breakthrough    
Abstract:
Parkinson’s disease (PD) remains a formidable challenge in neurology, with current therapies offering only symptomatic relief. The failure of intraputamenal glial cell line-derived neurotrophic factor (GDNF) infusion in Phase II trials (NCT01621581) underscores the limitations of invasive delivery and poor tissue penetration [1], while systemic GDNF administration is ineffective due to its inability to cross the blood–brain barrier (BBB) [2]. To address these challenges, I propose a novel, non-invasive strategy: exosomes engineered with rabies virus glycoprotein (RVG) for targeted delivery of GDNF mRNA to dopaminergic neurons in the substantia nigra (Fig. 1).
    
     
 
       

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