This paper offers a comprehensive examination of the static behavior of functionally graded antisymmetric angle-ply bio-inspired helicoidal carbon nanotube-reinforced laminated composite nanoplates for the first time. The influences of nanoscale and microstructure are examined using a modified nonlocal strain gradient continuum model. A newly developed Galerkin approach is utilized to analyze the static response of these plates. The global stability equations are derived using Hamilton's principle in conjunction with higher-order shear deformation theory. The analysis examines three distinct helicoidal CNTs configurations—helicoidal-linear (HL), helicoidal-exponential (HE), and helicoidal-semicircular (HS)—alongside four varieties of nanotube distribution patterns: UD, FG-X, FG-O, and FG-A. A comprehensive parametric analysis is conducted to examine the influence of geometric dimensions, material characteristics and boundary conditions on the buckling behavior of functionally graded, bio-inspired helicoidal laminated composite nanoplates.