Peripheral circulatory increase in CD4 + CD28 null T cells in CKD patients and this expansion elevated as CKD grades progress, this expansion was positively correlated to systemic inflammation and atherosclerosis; supporting a role of inflammation and immunity in initiation and progression of atherosclerosis. So CD4++ CD28null T cells may use as a marker of progression of chronic renal disease as same as atherosclerotic cardiovascular disease. So we must have searched blood level of CD4+CD28- and treated early to avoid its hazards.