This study investigates the propagation of nonlocal photoacoustic-diffusion waves in hydro-poroelastic semiconductors under variable thermal conductivity and chemical action. The study introduces a novel approach to understanding the interplay between photothermal and diffusion effects in a chemically active hydrosemiconductor medium, emphasizing the role of nonlocal poroelasticity. The governing equations are derived using generalized photo-thermoelasticity and poroelasticity theories, incorporating nonlocal effects, temperature-dependent thermal conductivity and chemical activity. The governing equations, derived using generalized photo-thermoelasticity and poroelasticity theories, are solved analytically through the normal mode method. The results are presented graphically to demonstrate the interplay of key physical parameters, including thermal conductivity, porosity, nonlocal effects, and chemical potential, on the propagation of photoacousticdiffusion waves. Comparative analyses reveal significant shifts in wave amplitudes and damping characteristics under different parameter conditions.