Dietary α-sitosterol mitigates titanium dioxide nanoparticle-induced hemato-immunotoxicity, oxidative stress, and gene expression dysregulation in Oreochromis niloticus

Faculty Veterinary Medicine Year: 2025
Type of Publication: ZU Hosted Pages:
Authors:
Walaa Alhuseiny Aldosouky Sliem
Journal: Frontiers in Marine Science Frontiers Volume:
Keywords : Dietary α-sitosterol mitigates titanium dioxide nanoparticle-induced    
Abstract:
Titanium dioxide nanoparticles (TDNPs) are widely used in food industries, agricultural and consumer products, and diagnostic purposes, leading to their potential release into aquatic environments and associated physiological risks to non-target aquatic organisms, particularly fish. α-Sitosterol (STL), a phytosterol, acts by enhancing antioxidant defenses and modulating inflammatory signaling pathways. Hence, this study investigated whether dietary STL can protect Nile tilapia (Oreochromis niloticus) from TDNPs-induced toxicity during a 60-day exposure.
    
     
 
       

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