LeadtoxicityinAfricancatfish:Promisingroleofmagnetitenanogelagainst etho-neurologicalalterations,antioxidantsuppression,genetoxicity,and histopathological/immunohistochemicaldisruptions

Faculty Veterinary Medicine Year: 2024
Type of Publication: ZU Hosted Pages:
Authors:
Heba Hassan hosny
Journal: Aquaculture ELSEVIER Volume:
Keywords : LeadtoxicityinAfricancatfish:Promisingroleofmagnetitenanogelagainst etho-neurologicalalterations,antioxidantsuppression,genetoxicity,and histopathological/immunohistochemicaldisruptions    
Abstract:
Recently,toxicitywithheavymetalshasbeenamajorhealthissuebecauseofitsdetrimentalimpactonfishand fishconsumers.Differentfrompreviousstudies,herewearethefirsttrial toassesstheimpendingeffectofthe waterysolutionofmagnetite (Fe3O4)nanogel (MG) against toxicityof lead(Pb) inAfricancatfish(Clarias gariepinus).Theevaluationincludedrecordingethology,brainfunction,antioxidanttraits,geneexpressionplus histopathological/andimmunohistochemicalassessmentandresidues inthebraintissues.Fish(n=160;Bwt: 100.00±7.39g)wererandomlyallottedintofourgroups (40/group;10fishper replicate; four replicates/ group).Thefirstgroup(control)wasnotexposedtoMGorleadchloride(PbCl2asasourceofPb).Thesecond (MG)groupwasexposedto1.2mg/LofMG.Thethirdgroup(Pb)wassubjectedtoPbCl2(69.30mg/L)toxicity. Meanwhile, thefourthgroup(MG+Pb)wassubjectedtoPbCl2 toxicity(69.30mg/L)andat thesametime, treatedwith1.2mg/LofMG.Thetrial lastedfor45days.TheexposuretoPbresultedinnotableethological alterations(unusualswimming,surfacing,lossofequilibrium,laterality,andspiralmovement).Acleardeclinein serumantioxidantparameters(catalase,reducedglutathionecontent,andtotalantioxidantcapacity)andbrain neurotransmitter(acetylcholineesterase)wasobservedinthePb-exposedfish.Anup-regulationofthemyeloid differentiationfactor88(MyD88),heatshockprotein70(HSP70),andtoll-likereceptor(TLR-1andTLR-5)genes of thebrainplushigher residual Pbdeposition inbraintissueswere inducedbyPbexposure.Additionally, prominenthistopathologicallesionsincludingneuronaldegenerationandvacuolationaswellasastrongcaspase 3andaweakB-celllymphoma2(bcl-2)immuneexpressionwereobviousinthebrain.Remarkably,theaddition ofMGinwater inducedan improvement in thesebiomarkers andretrieved thehistopathological changes. Consideringtheseoutcomes,MGisapromisingcandidateandaninnovativeapproachasantitoxicagainst the toxicityofPbforsustainingtheperformanceandhealthofAfricancatfish.
    
     
 
       

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