LeadtoxicityinAfricancatfish:Promisingroleofmagnetitenanogelagainst etho-neurologicalalterations,antioxidantsuppression,genetoxicity,and histopathological/immunohistochemicaldisruptions

Faculty Veterinary Medicine Year: 2024
Type of Publication: ZU Hosted Pages:
Authors:
Heba Hassan hosny
Journal: Aquaculture ELSEVIER Volume:
Keywords : LeadtoxicityinAfricancatfish:Promisingroleofmagnetitenanogelagainst etho-neurologicalalterations,antioxidantsuppression,genetoxicity,and histopathological/immunohistochemicaldisruptions    
Abstract:
Recently,toxicitywithheavymetalshasbeenamajorhealthissuebecauseofitsdetrimentalimpactonfishand fishconsumers.Differentfrompreviousstudies,herewearethefirsttrial toassesstheimpendingeffectofthe waterysolutionofmagnetite (Fe3O4)nanogel (MG) against toxicityof lead(Pb) inAfricancatfish(Clarias gariepinus).Theevaluationincludedrecordingethology,brainfunction,antioxidanttraits,geneexpressionplus histopathological/andimmunohistochemicalassessmentandresidues inthebraintissues.Fish(n=160;Bwt: 100.00±7.39g)wererandomlyallottedintofourgroups (40/group;10fishper replicate; four replicates/ group).Thefirstgroup(control)wasnotexposedtoMGorleadchloride(PbCl2asasourceofPb).Thesecond (MG)groupwasexposedto1.2mg/LofMG.Thethirdgroup(Pb)wassubjectedtoPbCl2(69.30mg/L)toxicity. Meanwhile, thefourthgroup(MG+Pb)wassubjectedtoPbCl2 toxicity(69.30mg/L)andat thesametime, treatedwith1.2mg/LofMG.Thetrial lastedfor45days.TheexposuretoPbresultedinnotableethological alterations(unusualswimming,surfacing,lossofequilibrium,laterality,andspiralmovement).Acleardeclinein serumantioxidantparameters(catalase,reducedglutathionecontent,andtotalantioxidantcapacity)andbrain neurotransmitter(acetylcholineesterase)wasobservedinthePb-exposedfish.Anup-regulationofthemyeloid differentiationfactor88(MyD88),heatshockprotein70(HSP70),andtoll-likereceptor(TLR-1andTLR-5)genes of thebrainplushigher residual Pbdeposition inbraintissueswere inducedbyPbexposure.Additionally, prominenthistopathologicallesionsincludingneuronaldegenerationandvacuolationaswellasastrongcaspase 3andaweakB-celllymphoma2(bcl-2)immuneexpressionwereobviousinthebrain.Remarkably,theaddition ofMGinwater inducedan improvement in thesebiomarkers andretrieved thehistopathological changes. Consideringtheseoutcomes,MGisapromisingcandidateandaninnovativeapproachasantitoxicagainst the toxicityofPbforsustainingtheperformanceandhealthofAfricancatfish.
    
     
 
       

Author Related Publications

  • Heba Hassan hosny, "Impact of silver nanoparticles exposure on neuro-behavior, hematology, and oxidative stress biomarkers of African catfish (Clarias gariepinus)", Elsevier, 2021 More
  • Heba Hassan hosny, "Synthesis and Characterization of AntibacterialCarbopol/ZnO Hybrid Nanoparticles Gel", MDPI, 2021 More
  • Heba Hassan hosny, "Chemically and Green Synthesized ZnO Nanoparticles AlterKey Immunological Molecules in Common Carp(Cyprinus carpio) Skin Mucus", MDPI, 2021 More
  • Heba Hassan hosny, "Physiological Performance, Antioxidant and Immune Status, Columnaris Resistance, and Growth of Nile Tilapia That Received Alchemilla vulgaris-Supplemented Diets", MDPI, 2022 More
  • Heba Hassan hosny, "Branchiomycosis in nile tilapia (oreochromis niloticus) in behira governorate with trials for treatment", Zagazig university, 2014 More

Department Related Publications

  • Hussein Ibrahim Hussin Elbelbesy , "Molecular detection of apoptosis in mice treated with ketoprofen and metamizol as analgesic drugs.", لايوجد, 1900 More
  • Hussein Ibrahim Hussin Elbelbesy , "The impact of staphylococcal mastitis on the level of milk IL-6 lysozyme and nitric oxide. ", لايوجد, 1900 More
  • Hussein Ibrahim Hussin Elbelbesy , "Experimental investigations and biochemical changes of curcumin on renal toxicity", لايوجد, 1900 More
  • Hussein Ibrahim Hussin Elbelbesy , "Effect of fasting and refeeding on serum leptin in correlation with insulin and glucose in pregnant and nonpregnant ewes. ", لايوجد, 1900 More
  • Hussein Ibrahim Hussin Elbelbesy , "Some microbiological , biochemical and clincopathological studies on the effect of Escherichia coli O157 :H7 in ducks. ", لايوجد, 1900 More
Tweet