Background and Aim: Asthma crosstalk has recently gained growing scientific attention, especially in the terrifying existence of COVID-19 that affected specifically the function of the respiratory system and led to death. Thus, this study aimed to determine how and if natural products as eugenol (Eug) and curcumin (Cur) can appoint the promising recovery and treatment of induced bronchial asthma. Methods: Forty male albino rats were included and randomly divided into five groups: Group I (control group), Group II (asthma group), Group III (Eug+Asthma group), Group IV (Cur+Asthma group), and Group V (Eug+Cur+Asthma group). Complete blood count (CBC) and biochemical estimation of serum urea, creatinine, and blood urea nitrogen (BUN) levels, lipid profile, and high-sensitivity C-reactive protein (hs-CRP) and pulmonary tissue homogenate levels were performed to evaluating inflammatory markers (IL‑1β, IL‑4, and TNF‑α). Results: Eug and Cur significantly improve urea, creatinine, and BUN levels and lipid profile. Moreover, restoring the normal levels of CBC and inflammatory markers (hs-CRP, IL‑1β, IL‑4, and TNF‑α) ameliorates the stress of asthma on the function of the respiratory system. Conclusion: Solitary and synergistic therapeutic effects of Eug and Cur on experimental induced asthma model owes principally to promoting the improvement of kidney and pulmonary functions by reducing inflammatory stress.