Including mobile microorganisms aids in stabilizing suspension of nanoparticles formed by the combined action of the magnetic field and buoyancy force. We have established activation energy using the Arrhenius function, and thermal conductivity of the physiological fluids utilized varies linearly with temperature in peristaltic flow of non-Newtonian nanofluid through microchannels. Relative importance of electric and magnetized forces, as well as quadratic thermal radiation and viscous dissipation are analyzed. Optimization of system entropy under the influence of all these variables is investigated. Wolfram program (Mathematica) then uses a built-in algorithm (ND-Solve function) to solve system of nonlinear simultaneous differential equations that it has created. Nu merical data and images emphasize significance of diverse physiological traits of flow volumes. Additionally, use of contour visualizations and circulatory bolus highlights one of the most notable peristaltic motion phenomena, trapping phenomenon. Results indicate that maximizing the Brinkman number leads to more advantageous characteristics of the heat transfer rate. It is possible to comprehend and use the peristaltic and electroosmosis processes in the development of complex lab-on-a-chip devices and microfluidic systems. This innovation boosts productivity and usefulness in fields that require accurate regulation of fluids at microscale, such as chemical detection and biomedical engineering.