Aim: This study aimed to evaluate the knowledge, attitudes, and acceptance of Electronic Health Records (EHRs) amongnurses in Egypt. Methods: A descriptive cross-sectional study was conducted involving 1217 nurses from 33 public and private hospitals. Data were collected using a self-administered online questionnaire, which assessed knowledge, atti tudes, and acceptance of EHRs. The data were analyzed using Spearman's rank correlation and binary logistic regression. Results: Significant positive correlations were identified between nurses' knowledge and attitudes towards EHRs (r =0.72,p <0.001), knowledgeand acceptance(r =0.67,p < 0.001),and attitudesand acceptance (r =0.79, p <0.001). Keypredictors of EHR acceptance included higher education (postgraduate) (p =0.004),goodcom puter skills (p < 0.001), satisfactory knowledge (p < 0.001), and positive attitudes (p <0.001). Conclusion: Nurses' knowledgeandattitudesplayacrucialroleintheiracceptanceofEHRs.Thesefindings under score the importance of targeted education and skill development programs to support the effective implemen tation of EHR systems in Egyptian healthcare settings. Implications to practice: Healthcare leaders and policymakers must champion the adoption of EHRs by creating policies that support their implementation. Creating a supportive environment that encourages the use of EHRs can significantly enhance their acceptance.technologies.