Due to climate change, abiotic stresses have arisen and are harming agricultural water management and agricultural productivity worldwide. To address this issue, bio-stimulators have been explored to improve water management and nutrient use efficiency, reflecting improved agricultural productivity due to suppression of climate change-induced stresses and the improved plant stress tolerance. Bio-stimulators play a dual role as they increase tolerance to abiotic stresses and feed the plant to adapt to stress and survive. Maize grain embryo extract (MGEE) and diluted bee-honey solution (DBHS) are a novel group of bio-stimulators recently used, beginning in 2014, for some crop plants (common bean, faba bean, sunflower, wheat, maize, onion, atriplex, roselle, and chili pepper) grown under certain abiotic stressors (salinity, drought, cadmium, nutrient deficiency, and chemical fertilizers). Reports signalized that MGEE and DBHS effectively induce improvements in molecular and morpho-physio-biochemical indices and positive stimulation of antioxidant defense systems, all of which enable plants to cope with stress-stimulated toxicity and maintain basic metabolic capacity under abiotic stress. Under the above-mentioned stresses, MGEE and DBHS can provide efficient mechanisms to enhance plant growth and yield traits, yield quality characteristics, photosynthetic efficiency, low-molecular-weight antioxidants, nutrient and hormonal homeostasis, antioxidant redox states, enzymatic antioxidant activities, antioxidant and polyamine gene expressions, etc. Extensive research into the potential of MGEE and DBHS to sustain plant performance under adverse field conditions would strengthen their potential as a cheaper and eco-friendly alternative to harmful and high-cost chemicals.