Background: Patients with COVID-19 infection may have an additional marker of outcomes with left ventricular (LV) strain evaluation by transthoracic echocardiography (TTE). Objective: This study aimed to use two-dimensional (2D) speckle-tracking echocardiography to evaluate left ventricular (LV) global longitudinal strain (GLS) in order to identify subclinical cardiac impairment among recovered cases from Covid-19 infection. Patients and methods: A case-control study in the isolation Hospital, Zagazig University in the duration from October 2021 to March 2022. We included 110 patients that were categorized in 2 groups according to clinical, radiological, laboratory and echocardiographic parameters: Group I: included patients recovered from Covid-19 (Study group). Group II: Non-Covid patients (Control group). This group included healthy subjects who have not encountered Covid-19 infection. Results: When comparing both groups, significant differences were found regarding echocardiographic data using speckle tracking. LVGLS was significantly decreased in cases compared to controls (19.18 ± 2.76 vs 21.58 ± 1.35, P<0.001), AP2GLS (18.90 ± 2.47 vs 21.58 ± 1.35, P<0.001), AP3GLS (20.28 ± 2.98 vs 21.94 ± 3.13, P = 0.005). A statistically significant difference existed between the two groups with respect to GLS, with all controls having a GLS value greater than – 18 and 27.3% of cases had decreased GLS < -18%. Conclusion: Patients with minimal cardiac risk who had recovered with home quarantine and had no symptoms may nevertheless have subclinical LV dysfunction which could be detected by LV-GLS in the early recovery period.