Arthroscopic Anterior Cruciate Ligament Reconstruction (ACLR) is recognized as the gold standard treatment in restoring static joint stability. Aim: This study aimed to evaluate the effect of educational program on nurses' performance post arthroscopic anterior cruciate ligament reconstruction and patients' outcomes. Design: A quasi-experimental research design was used. Setting: This study was conducted in Orthopedic Department, Arthroscopy Unit and Outpatient Arthroscopy Clinic attached to Zagazig University Hospitals. Subjects: A convenience sample of 30 nurses and a purposive sample of 60 patients. Tools: Nurses' structured interview questionnaire, Nurses' practice observational checklists, Patients' structured interview questionnaire, Patients' complications assessment questionnaire, and Patients' knee outcomes survey-activities of daily living scale. Results: There was a significant enhancement of nurses' knowledge and practice mean scores after program implementation than before with highly statistically significant differences as (P<0.01). There was a significant decrease in mean scores of complications post arthroscopic ACLR among study group patients after 2 and 4 weeks post program implementation than those in control group, with highly statistically significant differences between both groups with (P<0.01). There was a significant improvement in mean scores concerning knee symptoms and functional limitations with activities of daily living among study group patients after 2 and 4 weeks post program implementation than those in control group with highly statistically significant differences between both groups with (P<0.01). Conclusion: There was a statistically significant improvement of nurses' knowledge and practice post program implementation, which reflected on patients' outcomes improvement. Recommendations: Specialized nurses should be available in the outpatient arthroscopy clinic to provide patients with the needed instructions. Key Words: Arthroscopic Anterior Cruciate Ligament Reconstruction, Educational Program, Nurses' Performance, & Patients' Outcomes.