The mango shield scale, Milviscutulus mangiferae (Green) (Hemiptera: Coccidae) is considered as as one of the most serious pest infesting mango trees in Egypt. The impact of leaf anatomy of various mango varieties (Langra, Zebda and Ewais) on infestation with M. mangiferae was also documented. This investigation was conducted to study the susceptibility of certain mango varieties to infestation with the aforementioned insect. The population density of M. mangiferae was carried out during two successive seasons from January 2022 to December 2023 under the influence of the climatic factors on mango trees at the Horticulture Research Station in El-Qassasin district, Ismailia Governorate. The results obtained that during the first season, the population of M. mangiferae on Zebda and Ewais mango varieties had four peaks, whereas Langra recorded three peaks. In the second season, the activity periods of aforementioned insect varied among mango varieties, whereas Langra variety showed three peaks, Zebda variety had five peaks and Ewais variety displayed three peaks. There was a pronounced difference in the population density of this insect pest on the tested varieties. Coccophagus scutellaris (Dalman)( Hymenoptera: Aphelinidae) was identified as a parasitoid of M. mangiferae. Data revealed that a significant variation in susceptibility to M. mangiferae infestation among the mango varieties. Zebda variety was the most susceptible to this insect while Langra variety ranked second. In contrast, Ewais variety was resistant to infestation with this pest during the study period. climatic factors, the parasitoid and leaf anatomy of mango varieties had a significant effect on the population density of this insect. The present findings can be used for establishing IPM strategy against this insect pest.