This study introduces an innovative approach to desertification susceptibility mapping by integrating q-rung orthopair fuzzy sets (Q-ROFS) with a neutrosophic environment. Conducted in Matrouh, Egypt, the research quantifies desertification risk through advanced modeling techniques that address uncertainty and non-linearity in environmental data. The Q-ROFS framework enhances risk prediction by capturing complex relationships among desertification indicators. Neutrosophic logic, meanwhile, effectively addresses imprecision and ambiguity. The resulting susceptibility map clearly distinguishes between vulnerable and non-vulnerable regions, offering valuable guidance for policymakers and planners. The analysis revealed that approximately 79.98% of the study area falls under moderate susceptibility, 14.27% under high susceptibility, and only 5.75% under low susceptibility. These findings underscore the urgent need for sustainable interventions, especially in areas with moderate to high risk. A detailed sensitivity analysis further validated the model’s robustness and clarified the influence o