Background: Usually, neuromuscular blocking drugs are used for facilitating tracheal intubation but sometimes limitations exist as in procedures where neuromuscular monitoring is required or that of short duration. So, using an alternative method is important for providing good intubating conditions. Patients and methods: Eighty-eight patients in Zagazig University hospitals were randomly divided into two equal groups, group-M (Magnesium group) and group-P (high dose of propofol group). Group (M) received Magnesium sulfate (40 mg/kg), Fentanyl (2 μg/kg) and Propofol (2 mg/kg). Group (P) received Fentanyl (2 μg/kg) and Propofol (3 mg/kg). Assessment of quality of intubation conditions and hemodynamic response to tracheal intubation were done. Results: Group (M) had better intubation score and also less hemodynamic response to endotracheal intubation than group (P). Conclusion: Intravenous infusion of magnesium sulfate (40 mg/kg) before induction leading to better intubation score and also less haemodynamic response to endotracheal intubation than high dose of propofol.