The current research aims to identify the nature of gender differences (male / female), as well as differences between specialization (scientific / literary) in each of the three research variables (university freshmen Based on adaptability, perfectionism, and career decision-making difficulties). and, to identify the possibility of predicting university freshmen Based on adaptability as dimensions and total degree from the different dimensions of perfectionism, and to identify the possibility of predicting university freshmen Based on adaptability as dimensions and total degree from the different dimensions of career decision-making difficulties. The research scales were applied in their initial form to a pilot sample of (144) male and female students from the Faculty of Education, Zagazig University, for the academic year 2022/2023 AD. According to the academic specialization (85) from the scientific specialization, (59) from the literary specialization from the students of the first and second year at the Faculty of Education, Zagazig University, and the research scales were applied in their final form on a sample of (1607) male and female students from the students of the Faculty of Education, Zagazig University, for the year University 2022/2023; They were chosen randomly, distributed according to the gender variable to (198) male students, (1409) female students, and according to the academic specialization (916) from the scientific specialization, (691) from the literary specialization from students of the first and second years at the Faculty of Education, Zagazig University, in order to verify their The research hypotheses, and the statistical methods used were independent samples T-test, multiple regression analysis, and the structural equation model. The most important results indicated that there are differences between the gender differences (male / female), as well as the existence of differences between specialization (scientific / literary) in some dimensions of the three research variables, which are (university freshmen Based on adaptability, perfectionism, and career decision-making difficulties). The results indicated the possibility of predicting university freshmen Based on adaptability as dimensions and total degree from the different dimensions of perfectionism, as well as the possibility of predicting university freshmen Based on adaptability as dimensions and total degree from the different dimensions of career decision-making difficulties. Finally, the results indicate that a very large part of the effect of perfectionism on university freshmen Based on adaptability is through career decision-making difficulties.