Background: Women’s health is mostly affected by their quality of life; when it comes to breast cancer in particular, the loss of a breast traumatically affects a women’s quality of life. Health education and community health support are aids to improve these group health as well as their quality of life. The aims of this study are to determine aspects allied with quality of life among El-Beheira Governorate post-mastectomy women and assess the levels of women’s satisfaction regarding mobile-based health education. Research design: a descriptive research design was used. Settings: This study was carried out in Damanhour Oncology Center (DOC). Subjects: this study was carried out on a convenient sample of 200 women. Data collection tools: data were collected using two tools: the women’s structured interview questionnaire sheet and the Quality-of-Life Assessment Instrument (WHOQOL-100). Results: More than half of the studied women (56.0%) had poor quality of life, and the physical domain received the lowest percent score (45.24±16.07) followed by the spiritual domain (47.28±18.70). Conclusion: the study concluded that the Quality of life of post-mastectomy women on hormonal therapy may be positively affected in the domains of environment, and level of independence. Otherwise, it may be affected negatively in physical and spiritual health domains. Women were satisfied by the mobile-based health education delivered to them. Recommendations: Mobile-based health education must be intensified to raise public awareness and raise their QoL. Health education interventions to improve the quality of life of post-mastectomy women should be focused on the physical and spiritual health domains.