Modeling the causal relationships between Cognitive Bias, Persecutory Feeling, and Self- Esteem in university students Dr. Abdou Ali Abdou Soliman Lecturer of Mental Health Faculty Of Education-Zagazig University Abstract This research aimed to investigate the causal model that reflects the relationship between Cognitive Bias, Persecutory Feelings and Self-Esteem in the university students. The study sample consisted of 576 students from the first and fourth year enrolled in the Faculty of Education at Zagazig University, with (250) males and (326) females, aged between 18 and 21 years with (Mean= 19.5, SD = 1.11). They completed Cognitive Bias Scale, Persecutory Feeling Scale, and Self-Esteem Scale. The findings revealed the presence of a positive significant correlation at (0.01) between Cognitive Bias and Persecutory Feeling, and a negative significant correlation at (0.01) between Cognitive Bias and Self-Esteem, and also, there was a negative significant correlation at (0.01) between Persecutory Feeling and Self-Esteem. Moreover, the relationship between Cognitive Bias and Self-Esteem has been changed by isolating the effect of Persecutory Feeling. At the same time, some dimensions of cognitive bias and Persecutory Feeling predict Self-Esteem. The study variables (cognitive bias, Persecutory Feeling, self-esteem) shape a causal model that interprets the relationship between them, finally, the results showed that there was no significant effect for each of the gender (male - female) and specialization (scientific - literary) and the interaction between them on the research variables. Key words: Cognitive Bias, Persecutory Feeling, Self-Esteem, University Students.