Pesticide pollution of waterways is a significant problem that compromises the sustainability of aquaculture and harms the health of wild fish. The restoration potential of dietary white poplar leaves (WPL) during long-term hexaflumuron (HEX) exposure in Nile tilapia (Oreochromis niloticus) was studied for 60 days on growth, physiological, behavioral, gene expression, and histopathology assays. Two hundred fish (36.37±0.15 g) were split into four equal groups, each having five replicates. The CONT (control) and WPL groups received basal diets fortified with 0 and 6 g WPL/kg, respectively, and were not treated with HEX. In contrast, the HEX and WPL+HEX groups received the same feeding as the CONT and WPL groups, respectively, and were treated with 0.72 mg/L HEX.