This study investigated the potential neuroprotective role of Moringa oleifera leaf powder (MOLP) dietary supplementation on imidacloprid (IMD)-induced neurobehavioral disturbances, oxidative stress, and apoptosis in broiler chicken brains. In a 6 week trial, 150 day-old commercial meat-type Ross 308 broiler chicks were randomly divided into five equal groups of30 chicks each. The control and MOLP groups were fed a basal diet and a basal containing diet 25 g MOLP/kg, respectively, for 6 weeks. The IMD group was fed a basal diet for 2 weeks, followed by a basal diet containing 50 mg IMD/kg for 4 weeks. The IMD +MOLP combined group was fed a basal diet for 2 weeks, followed by a basal diet containing both IMD and MOLP for 4 weeks. The MOLP/IMD + MOLP prophylactic group was fed a MOLP-fortified diet for 2 weeks, followed by a basal diet containing both IMD and MOP for 4 weeks.