Triphosgene/KF-mediated acyl fluoride synthesis via in situ fluoro (chloro) phosgene

Faculty Science Year: 2025
Type of Publication: ZU Hosted Pages:
Authors:
Journal: Organic & Biomolecular Chemistry Royal Society of Chemistry Volume:
Keywords : Triphosgene/KF-mediated acyl fluoride synthesis , , situ fluoro    
Abstract:
The transformation of carboxylic acids into acyl fluorides via triphosgene-mediated deoxyfluorination utilizing inexpensive potassium fluoride (KF) has been achieved. This method affords a diverse range of acyl fluorides in high yields and exceptional purity. Analysis using 19F NMR spectroscopy reveals that fluorophosgene and chlorofluorophosgene, generated in situ, serve as the reactive intermediates crucial to the conversion process. The protocol exhibits excellent functional group tolerance, enabling late-stage modification of biologically relevant compounds, and is scalable for both lab and industrial use. Acyl fluorides also proved valuable as precursors for amides, organic intermediates, and fluorine donors.
    
     
 
       

Author Related Publications

    Department Related Publications

    • Maher Abdul Rahman Shams al-Din Safty, "Application of chemical reactions on thin-layer chromatography", لايوجد, 1900 More
    • weSam Saber Mohammed Shehab, "Synthesis,Characterization and Evaluation of the Anticancer and Antimicrobial Activities of Some Novel Benzazole and Benzazine Derivatives", Council for Innovative Research, 2013 More
    • Wael Salah AbdelHalim, "Spin quenching of transition metals deposited on MgO insulator and CdO semiconductor density functional calculations", Wiley, 2011 More
    • Wael Salah AbdelHalim, "CO adsorption on Ni, Pd, Cu and Ag deposited on MgO, CaO, SrO and BaO: Density functional calculations", elsevier, 2009 More
    • Walaa Helmy Fahmy Sheweny, "SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY OF NEW Y(ΙΙΙ) AND Zr(ΙV) CIPROFLOXACIN COMPLEXES", LATVIJAS ĶĪMIJAS ŽURNĀLS, 2010 More
    Tweet