Given the high aspect ratio and larger surface area of nanostructured materials, nanocomposites are essential catalysts in organic processes. The rate and yield of the product are enhanced during the reaction due to the significant interfacial contact of the reactant with the surface of nanocomposites. A critical investigation of the role of nanocomposites in chemical reactions (Reduction, oxidation, epoxidation, Knoevenagel Michael condensation and coupling reactions) to synthesize different organic nuclei is shown in the current review. Different transition metal-based nanocomposites track organic reaction selectivity as well as changes in yields, reaction time, atom economy, and solvent influence. Numerous recognized green one-pot synthesis methods for organic nuclei. These methods also include the use of different nano catalysts. Therefore, the current study investigates novel approaches to the replacement of conventional catalysts and reagents in organic synthesis with transition metal-based nanostructured catalysts, adhering to green chemistry principles.