The aim of this research is knowing the predictability of perceived self-efficacy and the goal orientation on cognitive interference and the attitudes towards blended learning among students of the Faculty of Education at Zagazig University, and it also aimed to know the differences in both cognitive interference and the attitudes towards blended learning according to Levels of cognitive interference and the attitudes towards blended learning among university students .The sample consisted of (581) male and female students from the first and fourth grades at the Faculty of Education - Zagazig University. We used Pearson's correlation coefficient and the multiple regression equation model: there is a negative statistically significant relationship between cognitive interference and both Competence Self-Perception and goal orientation in the research sample, while there is a positive significant relationship Statistically between the attitdues towards blended learning and the Competence Self-Perception and goal orientation of the research sample. It can be predicted from the Competence Self-Perception and goal orientation on cognitive interference and the attitudes towards blended learning among the research sample