Background: Hemodynamic instability is the most common problem of patients post cardiothoracic surgeries. Many studies reported that reflexology improves hemodynamic instability post- cardiothoracic surgeries. Nurses play a critical role in stabilizing hemodynamic status post- cardiothoracic surgeries. The study aimed to evaluate the effect of reflexology on hemodynamic status regarding patients with cardiothoracic surgeries. Setting: The study was conducted in the cardiothoracic intensive care units in cardiothoracic hospital at Sednawy Zagazig University Hospital., Egypt. Subjects: A purposive sample of 80 patients who were admitted to the cardiothoracic surgery department and were subjected to cardiothoracic surgery during the study period divided into two groups of patients (study and control), (40 patient) for each group. Two tools were used for collection of data, structured interview questionnaire to assess demographic and health history assessment data for patients and patients’ hemodynamic assessment questionnaire to assess hemodynamic status. Results: There was a statistically significant difference between the two groups in hemodynamic status variables as respiratory rate, pulse, oxygen saturation, blood pressure, skin color, mucous membrane, lips color and nail color after applying hands and foot reflexology and the improvement were more significant in reflexology group than control group. Conclusion: Hands and foot reflexology has positive effect in stabilizing the hemodynamic status of patients after cardiothoracic surgeries. Recommendations: This study recommended periodic evaluation and validation of the training given and training programs should be included both theoretical and practical to patients who prepared for cardiothoracic surgery on cardiothoracic surgery units and their relatives.