The current research aimed to develop some knowledge management skills and self-efficacy beliefs among student teachers at the College of Education, in order to achieve that, a training program was proposed based on the 21st Century Competencies and Egypt Vision 2030 for Education. In light of this, a research group consisting of (40) male and female students was selected from the two divisions (Biology - Chemistry) in the third year of the Faculty of Education - Zagazig University for the second semester. For the academic year 2021-2022, the two research tools were represented in the gradual performance scale for knowledge management skills, which consisted of five skills represented in (identifying knowledge - storing knowledge - applying knowledge - spreading and sharing knowledge - evaluating knowledge), and the self-efficacy scale that consisted of four dimensions, It was represented in (classroom management efficacy- Student Engagement Efficacy - Instructional Practices Efficacy - Using Technology Efficacy). The two search tools were applied remotely, SPSS. Ver. 27 program was used To process the data, used the Paired sample t-test, and calculate the effect size of the experimental treatment. the results indicated that the students of the research group excelled in the post application over the tribal application with a statistically significant difference at the level (0.01) in terms of developing both knowledge management skills and Self-efficacy beliefs, and it also resulted in the effectiveness of the proposed training program in developing specific knowledge management skills and self-efficacy beliefs. The research presented its recommendations and proposals in light of the results reached, including the need to pay attention to university education based on modern trends such as the 21st Century Competencies and Egypt Vision 2030 for Education.