Introduction: Nowadays, the impact of acne on the psyche of patients is evident to physicians and patients themselves. Studies concerned with the relation between acne and quality of life (QOL) are scarce in the Middle East. Methods: This prospective cross-sectional study included 247 patients. The severity of acne was evaluated using the Global Acne Grading System (GAGS). Then, patients were asked to fill in the Arabic versions of the Dermatology Life Quality Index (DLQI) and the Cardiff Acne Disability Index (CADI). Results: The mean CADI and DLQI scores were 6 ± 3.2 and 9.8 ± 5.5, respectively. There was a weakly significant positive correlation between CADI and GAGS, gender, cheek, chin, chest, and upper back localization of lesions (p ≤ 0.05). Moreover, there was a weakly significant positive correlation between only GAGS and DLQI (r = 0.125, p = 0.000). Conclusion: Acne has an evident negative impact on the QOL of the participants. Assessing the QOL of acne patients and psychiatric consultation are advised to be standard measures of any management approach for acne patients for their well-being.