Background: Numerous studies have shown that the lactate/albumin ratio can be used as an early prognostic indication in hepatic patients. To predict negative outcomes when hepatic decompensation is present, it became necessary to determine the clinical importance and offer fresh perspectives on the predictive usefulness of these straightforward and easily accessible regular serum indicators. Therefore, our goal was to determine whether lactate/albumin ratio might be used to predict in-hospital mortality in patients with cirrhosis who were admitted to the hospital. Methods: This prospective study was conducted on 60 cirrhotic patients who attended the Intensive Care Unit (ICU) in the Internal Medicine Department at Zagazig University Hospital, Egypt. Lactate/Albumin Ratio was measured in all cases. Results: Lactate /Albumin that were significantly higher in death group than alive group. At a cut off 1.2, lactate/albumin showed AUC=0.795 with sensitivity 58.1%, 94.9% specificity and p value 0.003 in prediction of death among advanced liver cirrhotic patients. Conclusion: Lactate/albumin ratio is a promising and easily accessible biomarker for predicting the mortality of individuals with decompensated cirrhosis. Regarding the in-hospital mortality of decompensated cirrhotic patients, the lactate/albumin ratio is considered a useful biomarker for outcome prediction.