Vaginal infections (VI) are a global health problem for women at reproductive age. These infections threat the women’s health and have negative impacts on their quality of life (QOL). Aim of the study: Assess the risk factors and quality of life among women diagnosed with vaginal infections. . Subjects and methods: Research Design: The study was descriptive research design .Setting: The study was conducted among women attend obstetric and gynecological outpatient clinics at zag azig University hospitals. Subjects: included all accessible of women aged 20-45 years Tool of data collection: two tools were used: first: A structured interviewing questionnaire form and the second tool quality of life form about vaginal infection . Results revealed that the infected women with vaginal infection were most likely to have effect on emotional well-being and role limitation due to physical problem with a mean ± SD (62.1±11.5 and 59.3±16.8 respectively).As well as mean of Physical functioning (pf) for these studied women (51.7±17.4).Conclusion: The study finding concluded that there is a relation between vaginal infection and health related quality of life in women diagnosed with vaginal infection, and The study also revealed that the disease has a strong impact on patient’s usual daily activiti