Cervical cancer is cancer of the cervix, extending into the upper end of the vagina. Cervical cancer is mainly caused by persistent infection with certain types of human papillomavirus (HPV), including sixteen and eighteen types responsible for approximately 70% of cervical cancer cases worldwide. Cervical cancer is both a preventable and treatable disease.Vaccination against the human papillomavirus (HPV) has been shown to prevent cervical cancer and genital warts. A lack of knowledge about HPV and low levels of understanding of HPV vaccination has direct implications for women’s participation in cervical cancer. Despite this, the importance of health education as an integral part of primary prevention for cervical cancer is often ignored. (Tiiti et al., 2022). Maternity nurses had a gold role in prevention of cervical cancer as maternity nurses are key person in health care delivery system. Nurses should educate women at different ages to improve knowledge and attitude. Nurses may be able to apply the knowledge in to practice & assume responsibility & accountability for women's & eventually help to improve the reproductive health of the women & can prevent morbidity & mortality of women due to cervical cancer (Lebuso., 2022). Aim of the study: The aim of this study was to evaluate the effect of an educational intervention based on health belief model on nurses’ knowledge and practice regarding human papillomavirus and cervical cancer and answers the research objectives. Such aim was fulfilled through the following objectives: 1- Assess nurses’ knowledge regarding human papillomavirus and cervical cancer. 2- Assess nurses’ practice regarding human papillomavirus and cervical cancer