Background: Papillary thyroid carcinoma (PTC) is the most common histological type of thyroid cancer. Fortunately, most PTC patients have favorable outcomes, but about 20% of patients,have distant metastases. Therefore, the exploration of new biomarkers to know new characteristics of PTC should be updated. Aim : evaluate the possible role of Dynamin-2 and Angiopoietin-like protein 2 (Anglp2) as novel prognostic markers for papillary thyroid carcinoma. Material and Methods: In our study, we investigated the expression of DNM2 and Anglp2 in 60 cases of PTC . The clinical significance of the markers was evaluated by assessing correlation with the clinicopathological parameters. Results: High DNM2 expression PTC was significantly associated with advanced tumor stage, lymph node metastasis, recurrence and death ( p<0.002,0.018, <0.001, <0.001respectivelly).High expression levels of Anglp2 in PTC were significantly associated with advanced tumor stage, , recurrence and death (p <0.004, ,p= 0.004,p=0.003 respectively). Conclusions: DNM2 and Anglp2 were independent PTC markers indicating more likely recurrence and poor prognosis. Expression may help to select the high-risk patients for adjuvant targeted therapy.