Electrocoagulation (EC) is one of the efficient electrochemical approaches for industrial wastewater treatment. The present work aims to reach optimum conditions for achieving simultaneous removal of chromium and cadmium ions from synthetic wastewater by EC through assessment of different parameters like electrodes material, electrode configuration, initial pH, current density, initial temperature, and initial contaminate concentration. In addition, a comparison between chemical coagulation and EC efficiency for Chromium and cadmium removal was presented. Results showed that the (Fe-Al), an anode and cathode, achieved better removal efficiency than other electrodes configurations (Fe-Fe / Al-Fe / Al- Al). Also, the increase of initial temperature and current density enhanced the removal efficiency. In contrast, the increase in the initial concentration reduced the removal efficiency. The complete removal of Chromium achieved through the use of Fe-Al electrodes and current density was 12.50 mA/cm2 with solution pH of 5.8, temperature was 25oC and an initial concentration of 280 mg/L. On the other hand, Cadmium’s complete removal was achieved through the use of Fe-Allectrodes, at pH of 5.8, applied current 1.4 A and 60oC. Therefore, EC was proved to be better approach than conventional coagulation in case of treatment of wastewater containing different types of heavy metals ions with high initial concentrations.