This quasi-experimental study aimed to evaluate the effectiveness of nursing interventions in enhancing elderly self-care for preventing recurrent urinary tract infections. A purposive sample of 150 elderly individuals with UTIs was divided into a study group (n=75), which received both standard care and nursing intervention about self-care practices for preventing recurrent urinary tract infections, and a control group (n=75), which received only the standard care protocol. The study was conducted in the urology outpatient clinics at Zagazig University Hospitals. Two tools were used; Structured Interview Questionnaire on Demographic characteristic, Health History, and Self -Care Practice Assessment. The study findings showed that 8.0% of the study group had total satisfactory self-practice pre-intervention while, (84% & 81.3%) of them had total satisfactory self-practice post-test and follow-up, respectively, compared to (8.0% & 6.7%) in the control group. Factors such as income (sufficient), previous work experience (housewife), and education level (illiterate) have a significantly positive effect on total self-practice post-intervention with p-values of 0.027, 0.004, and 0.006, respectively. Both the study and control groups exhibited an overall deficiency in self-care practices related to recurrent urinary tract infections (RUTIs) during the pre-intervention phase. However, post-intervention results provide evidence confirming the effectiveness of the nursing intervention in significantly improving self-care practices among the elderly in the study group. Implement continuous self-care practice nursing intervention program for urinary tract infection in outpatient clinics and urology departments.