This study sought to improve the emotional wellbeing and reduce stress by applying Mindfulness-based intervention among mothers of children with autism spectrum disorder (ASD) in Egypt. The participants consisted of 30 mothers of children with ASD, however 6 mothers participated in the counselling study, mothers aged 32-56 years (M=39.3, SD=6.96). Mindfulness Scale (Baer et al. 2006), MHC–SF (Keyes 2009) and DASS-21(Lovibond &Lovibond 1995) were applied in this study along with the mindfulness counselling program for mothers (author). Findings indicated significant results, most importantly of which statistically significant differences after implementing the program, a significant increase in mindfulness and wellbeing and a decrease in anxiety, depression, and stress levels among participating mothers. No significant differences were reported after three month follow up. Furthermore, mothers reported positive feedback regarding participating in the mindfulness program. The study recommended conducting research focusing on intervention mindfulness programs to treat various mental health disorders, especially anxiety and depression. Keywords: Mindfulness –Emotional Wellbeing- Mothers of children with SD- Stress