Background: The nursing profession is a challenging one, with nurses working under pressure all the time. The development of a healthy work environment and resilience skills is essential for nursing personnel to adapt to these obstacles and advance their careers. Aim of the study: Was to determine the relation between work environment and resilience among nursing staff at Zagazig University Hospitals. Subject and methods: Research design: A descriptive correlation research design was utilized in this study. Setting: This study was conducted at Zagazig University Hospitals. Subjects: stratified random sample of 375 nursing staff working at Zagazig University Hospitals. Tools of data collection: Two tools were used: the Practice Work Environment questionnaire and the ConnorDavidson Resilience Scale (CD-RISC). Results: 42.9% of nursing staff had a low perception level toward their nursing work environment, and more than half of them (59.5%) possessed a great degree of resilithe workplace. rkplace.Conclusion: A statistically significant positive connection was shown between nursing staff perception toward their work environment and their resilience. Recommendations: Implementing effective strategies by health care organizations to improve nursing staff perception about the nursing work environment to enhance resilience and better thriving at work.