Background: The change in a woman's life from being fertile to infertile is known as menopause and it is a bio psychological process. Aim of the study: was to assess stress and marital adaptation among menopausal working women. Subjects and Methods: Design: A descriptive cross sectional was utilized. Setting: The current study was conducted at Zagazig University among menopausal working women. Sample: About 160 menopausal working women made up the purposive sample. Tools: Data from three sources were used: Tool I; structured interview form consists of demographics, medical history, and menstrual history, Tool II: Arabic version perceived stress scale and Tool III: dyadic adjustment scale. Results: About 83.1% of the study sample had moderate stress level and 75% of them had maximum level of marital adaptation. Highly statistically significant relation was found between marital adaptation and stress level. Conclusion: Menopausal working women's ability to adjust to marriage is negatively impacted by stress. Recommendation: Nursing interventions that use different stress management approaches to reduce stress may aid in successful marital adaptation.