The organophosphorous insecticides (OPIs) is widely used. The toxicity of OPIs is related to many biochemical disorders, for example changes in serum amylase and lipase enzymes. Average duration of admission affects prognosis of poisoning severity and outcome. The aim of this work was to evaluate the role of average days of admission, serum amylase and lipase enzymes in assessing OPIs poisoning severity, outcome, and complications in acutely OPIs poisoned patients admitted to Poison control center at Zagazig University Hospitals. This study was carried out on 36 OPIs poisoned patients on 7 months duration from May 2019 till November 2019. We scored the cases on first day of admission using POP score. Serum amylase and lipase were calculated on the day of admission and repeated after 24h. Results: Cases ranged between 3 and 66 years old with a mean age of 32.7±17.96. Serum amylase was correlated with OPIs poisoning severity, outcome, and complications, but not predictor of them. Serum lipase was not correlated with OPIs poisoning severity, outcome, and complications. Average days of admission were correlated with OPIs poisoning severity, outcome, and complications but predictor of outcome only. It is recommended to do further studies with large sample size for more accurate evaluation of the correlation with organophosphorous insecticides poisoning.