Background and study aim: Regarding the increased number of chronic liver diseases (CLD) patients suffering from many manifestations e.g. diarrhea, this withdrew our attention to try to find a relation between CLD and parasitic infections in those patients. Patients and Methods: A case-control study was performed on 190 participants suffering from gastrointestinal complaints especially diarrhea attending Gastroenterology and Hepatology Outpatient Clinics at Zagazig University Hospital, divided into 2 groups GI: 95 CLD patients. GII: 95 non-CLD Control group patients. Cases underwent clinical, abdominal ultrasonographic, and laboratory liver function assessments. Also, collected patients’ stool samples were microscopically examined using iodine, Trichrome and Modified ZiehlNeelsen stains. To confirm accurate diagnosis to parasitic infections causing diarrhea, RIDA-ELISA for Cryptosporidium spp. and Giardia lamblia copro-antigens detections was performed. Results: Parasitic infections among both studied groups were (47%), comprising (58%) in CLD and (36%) in non-CLD as follow: Cryptosporidium (28%, 14%), Giardia (15%, 12%), mixed (5%, 3%), E.histolytica spp. (5%, 4%), Blastocystis hominis (3%, 1%) and H. nana (1%, 2%) respectively. The sensitivity, specificity, PPV, NPP and accuracy of ELISA regarding Giardia and Cryptosporidium infections were (100% and 89.6%, 97.5% and 100%, 87.9% and 100%, 100% and 96.6%, 97.9% and 98.4%) respectively. In GI, most giardial cases had normal ALT and AST levels (74%, 63%), but elevated in cryptosporidial infection (59%, 66%) respectively, with statistically significant difference. Conclusion: Presence of intestinal parasitic infections; mainly Cryptosporidia and Giardia protozoa among CLD patients was striking when compared to diarrheic non-CLD control group and this may be attributed to impaired immune status.