Prognostic impact of age on outcomes of hepatic decompensation in patients with compensated cirrhosis (CHESS2102): an international, multicenter cohort study

Faculty Medicine Year: 2024
Type of Publication: ZU Hosted Pages:
Authors:
Journal: MedComm Wiley Volume:
Keywords : Prognostic impact , , , outcomes , hepatic decompensation , patients    
Abstract:
Baveno VII criteria (B7C) and Baveno VI criteria (B6C) have been widely used to estimate the risk of hepatic decompensation. However, the impact of age on these criteria warrants further investigation. The international, multicenter cohort study included 1138 patients with compensated cirrhosis (median follow-up of 40.6 months), aiming to evaluate the value of age in predicting hepatic decompensation. We identified age as an independent predictor of hepatic decompensation, with 60 years determined as the optimal cut-off value. The occurrence of decompensation was 18.7% and 6.7% in the older (age ≥60 years) and younger (age <60 years) groups, respectively (p < 0.001). We subsequently integrated age into the existing Baveno criteria. In patients not meeting Baveno criteria (defined as not meeting B6C or B7C), the older group exhibited a significantly elevated risk of decompensation compared to the younger group (p < 0.05). However, no significant difference was observed between the older and younger groups in patients meeting Baveno criteria (p > 0.05). In conclusion, our study demonstrated that integrating age into the Baveno criteria could enhance the assessment of hepatic decompensation. Age should be considered before discharging patients with compensated cirrhosis from the surveillance of hepatic decompensation.
   
     
 
       

Author Related Publications

  • Amro Shaban Hanafy Elsayed, "Efficacy of low dose capecitabine and sorafenib in patients with advanced alfa-fetoprotein secreting hepatocellular carcinoma: a one year experience.", springer, 2016 More
  • Amro Shaban Hanafy Elsayed, "efficacy of argon plasma coagulation in the management of portal hypertensive gastropathy", thieme publishers, 2016 More
  • Amro Shaban Hanafy Elsayed, "Association of thrombogenic genes polymorphisms with hepatocellular carcinoma in HCV Egyptian patients. Gene 2016;580: 37–40", Elsevier, 2016 More
  • Amro Shaban Hanafy Elsayed, "Association of thrombogenic gene polymorphisms with hepatocellular carcinoma in HCV Egyptian patients", Elsiever, 2016 More
  • Amro Shaban Hanafy Elsayed, "Randomized Controlled Study Comparing Use of Propofol Plus Fentanyl versus Midazolam Plus Fentanyl as Sedation in Diagnostic Endoscopy in Patients with Advanced Liver Disease", HINDAWI, 2017 More

Department Related Publications

  • Ahmed Adel Hassan Muhamad, "تأثير فصائل الدم بنظام "أ ب و" على تحفيز المختل زراعة كلى لهم", لايوجد, 1900 More
  • Ahmed Abdelshafy Hilal, "الدور المحتمل للماغنسيوم في مرضي الربو الشعبي", لايوجد, 1900 More
  • Usama Mohamed Ahmed Hassanein, "دراسة تاثير اشتباه الهيبارين الداخلية والاتهابات البيكتيرية علي دوالي المرئ النازفة لدى مرض تليف الكبد", لايوجد, 1900 More
  • Ehab Barsom Fahim Meawad, "زلال البول والسكتة الدماغية فى مرضى السكر من النوع الثانى", لايوجد, 1900 More
  • Gehan Abdelkader Ibrahim, "زلال البول والسكتة الدماغية في مرض السكر من النوع الثاني", لايوجد, 1900 More
Tweet