Implementation of analytical quality by design concepts for the optimization of quantitative 1H nuclear magnetic resonance (1 H-qNMR) method for quantitation of novel anti-covid drugs (molnupiravir and favipiravir) in their pharmaceutical dosage forms

Faculty Science Year: 2024
Type of Publication: ZU Hosted Pages:
Authors:
Ayman AboulFotouh Gouda Sallem
Journal: Microchemical Journal United States Volume:
Keywords : Implementation , analytical quality , design concepts , , optimization    
Abstract:
طُبّقت مبادئ الجودة التحليلية بالتصميم (AQbD) على تطوير طريقة رنين نووي مغناطيسي كمّي مُحدّدة وبسيطة للبروتون (1H-qNMR) لقياس كمية دواءين مضادين للفيروسات، هما مولنوبيرافير (MOL) وفافيبيرافير (FAV). طُوّرت هذه الطريقة ضمن إطار الجودة التحليلية بالتصميم (QbD)، وهو النموذج الجديد للجودة الذي وُضّح مؤخرًا في إرشادات ICH Q14.
    
     
 
       

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