Introduction: EG.5, also known as "Eris," is among the most widespread and concerning forms of the coronavirus globally. The proportion of EG.5 cases has steadily increased (Girma, 2023). Recent testing confirms the rise of this new variant, with experts attributing its spread to mutations in the spike protein that enhance immune Shirking. These genomic changes likely contribute to modest increases in hospital admissions (Dyer, 2023). By May 7, 2023, 13.4 billion COVID-19 vaccine doses had been given across the world. However, the virus's dynamic nature continues to give rise to new variants, including EG.5. The symptoms of EG.5 align with general COVID-19 symptoms, ranging from minimal to intense. Common symptoms comprise cough, pyrexia, chills, breathlessness, tiredness, muscle soreness, absence of taste or anosmia, and headaches. EG.5 is also associated with runny nose, sneezing, and dry cough (Oscar & Stella, 2023). As an Omicron descendant, EG.5 shares similar characteristics, with reinfection risks influenced by age, location, and health equity Aim of the study: To assess effectiveness of nursing program in preparing nurses for the care of patients with epsilon gamma5. Hypothesis Nursing program has a notable influence in preparing nurses for the care of sick individuals with epsilon gamma5. Research Design: A quasi-experimental research design was utilized to conduct the study. Study setting: The study was performed at Mansoura fever Hospital. Study Sample: A sample of convenience that includes all nurses (40 nurses) who were working at the fever hospital in Mansoura. Tools for data collection: Three instruments were implemented for collecting data to achieve the study’s objectives: 1 Tool One: Self-Administered Knowledge Questionnaire This tool was developed by the researchers examined the latest national and international literature. It is divided into two parts:  Part 1: Demographic Data Sheet This section collects participants' demographic information, including age, marital status, gender, educational level, years of experience, and attendance of training courses related to epsilon gamma5.  Part 2: Self-Administered Knowledge Questionnaire This section includes 43 items covering various aspects of epsilon gamma5, such as its definition, effects on the human body, manifestations, complications, treatment, prevention, and nursing interventions. Tool Two: observational Nurses’ Practices Checklist Tool Three: Self- administered Nurses’ Attitudes Likert Scale Pilot study: In September 2023, a pilot study was performed to evaluate the feasibility and practicality of the study tools. The study included 10% of the total sample (4 nurses) and also helped estimate the time necessary to complete the tools. Field work Assessment phase During this stage, Assessment of nurse's knowledge, attitude and practices will be done using the first study tool: Researcher started data collection by distributing knowledge questionnaire to gather data regarding nurses’ characteristics and their understanding of the care of patients with epsilon gamma5. Planning Phase The researcher conducted a thorough review of pertinent literature for the study, examining both local and international sources, including textbooks, articles, and scientific journals. Execution Phase Nurses were organized into 5 groups. Every group consisted of 8 nurses. Each group received 2 sessions for assessment, and 4 educational sessions. Each nurse in the study sample received a copy of the designed nursing educational program booklet which outlined nursing care activities. Evaluation phase: In this phase, evaluating the effectiveness of the nursing program will be done using knowledge, attitude, and practices questionnaire after implementation of the program. 1 Results: Revealed that prior to the program, only 22.5% of nurses’ demonstrated good knowledge of EG5, increasing to 75% post-program. Similarly, satisfactory practice scores improved from 35% pre-program to 67.5% post-program. Attitudes also shifted positively, with positive attitudes increasing from 40% to 70% and negative attitudes dropping from 60% to 30% after the program. Conclusion: The study’s results concluded that the nursing program has positive effects on improving nurses' knowledge, practice and attitude related to the nursing care for patients with epsilon gamma5. The nurses who received the nursing program had better level of knowledge, practice and attitude than before implementing of nursing program. Recommendation: Based on the findings of the recent study, the following recommendations are proposed: Replication of this study on larger sample of nurses in different hospitals. An Arabic nursing guidelines about the care for patients with epsilon gamma5 should be distributed for each newly worked nurse.