Structural simplification of Osimertinib to elaborate new indolyle-pyrimidine-5-carbonitrile derivatives with Anti-proliferative and Anti-SARS-CoV-2 activities assisted by molecular dynamic simulation

Faculty Science Year: 2024
Type of Publication: ZU Hosted Pages:
Authors:
Ahmed Fouad Mohamed Elsayed Elfarargy
Journal: Tetrahedron Elsevier Volume:
Keywords : Structural simplification , Osimertinib , elaborate new indolyle-pyrimidine-5-carbonitrile derivatives    
Abstract:
Structural simplification of Osimertinib to elaborate new indolyle-pyrimidine-5-carbonitrile derivatives with Anti-proliferative and Anti-SARS-CoV-2 activities assisted by molecular dynamic simulation
    
     
 
       

Author Related Publications

  • Ahmed Fouad Mohamed Elsayed Elfarargy, "Design, Synthesis, Molecular docking and antimicrobial activity of novel thiazolo[5,4-c]pyridine glycoside and thiazolo[4,5-d]pyrimidine glycoide", Taylor and Francis, 2021 More
  • Ahmed Fouad Mohamed Elsayed Elfarargy, "Effective pharmacophore for CDC25 phosphates enzyme inhibitors: newly synthesized bromothiazolopyrimidine derivatives", Bentham science, 2021 More
  • Ahmed Fouad Mohamed Elsayed Elfarargy, "Enhancement the detection of Ni2+ and Zn2+ ions using nanostructure of synthesized dithiol surfactants with gold nanoparticles", Journal of Industrial and Engineering Chemistry, 2014 More
  • Ahmed Fouad Mohamed Elsayed Elfarargy, "Zinc(II) modified carbon paste electrodes based on self-assembled mercapto compounds-gold-nanoparticles for its determination in water samples", Journal of Industrial and Engineering Chemistry, 2014 More
  • Ahmed Fouad Mohamed Elsayed Elfarargy, "Detection of Heavy Metal Ions Using Synthesized Amino Thiol Surfactants Assembled on Gold Nanoparticles", Journal of Dispersion Science and Technology, 2014 More

Department Related Publications

  • Abd El Shafey Ibrahim Ahmed Ibrahim, "Optimizing halogenation conditions of N-halamine polymers and investigating mode of bactericidal action", Copyright © 2009 Wiley Periodicals, Inc., 2009 More
  • Maher Abdul Rahman Shams al-Din Safty, "Kinetic studies for pyrolysis of wheat straw", لايوجد, 1900 More
  • Maher Abdul Rahman Shams al-Din Safty, "some reactions with 1,4 diphenyl - 1:2 , 3:4 - diepoxybutane", لايوجد, 1900 More
  • Maher Abdul Rahman Shams al-Din Safty, "structural group analysis of asphaltic fractions of U.A.R. crude oils ", لايوجد, 1900 More
  • Maher Abdul Rahman Shams al-Din Safty, "preparation and some reactions of 1:4 diaryl - 1,3 dicarboxaldehyde", لايوجد, 1900 More
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