Structural simplification of Osimertinib to elaborate new indolyle-pyrimidine-5-carbonitrile derivatives with Anti-proliferative and Anti-SARS-CoV-2 activities assisted by molecular dynamic simulation

Faculty Science Year: 2024
Type of Publication: ZU Hosted Pages:
Authors:
Ahmed Fouad Mohamed Elsayed Elfarargy
Journal: Tetrahedron Elsevier Volume:
Keywords : Structural simplification , Osimertinib , elaborate new indolyle-pyrimidine-5-carbonitrile derivatives    
Abstract:
Structural simplification of Osimertinib to elaborate new indolyle-pyrimidine-5-carbonitrile derivatives with Anti-proliferative and Anti-SARS-CoV-2 activities assisted by molecular dynamic simulation
    
     
 
       

Author Related Publications

  • Ahmed Fouad Mohamed Elsayed Elfarargy, "Design, Synthesis, Molecular docking and antimicrobial activity of novel thiazolo[5,4-c]pyridine glycoside and thiazolo[4,5-d]pyrimidine glycoide", Taylor and Francis, 2021 More
  • Ahmed Fouad Mohamed Elsayed Elfarargy, "Effective pharmacophore for CDC25 phosphates enzyme inhibitors: newly synthesized bromothiazolopyrimidine derivatives", Bentham science, 2021 More
  • Ahmed Fouad Mohamed Elsayed Elfarargy, "Enhancement the detection of Ni2+ and Zn2+ ions using nanostructure of synthesized dithiol surfactants with gold nanoparticles", Journal of Industrial and Engineering Chemistry, 2014 More
  • Ahmed Fouad Mohamed Elsayed Elfarargy, "Zinc(II) modified carbon paste electrodes based on self-assembled mercapto compounds-gold-nanoparticles for its determination in water samples", Journal of Industrial and Engineering Chemistry, 2014 More
  • Ahmed Fouad Mohamed Elsayed Elfarargy, "Detection of Heavy Metal Ions Using Synthesized Amino Thiol Surfactants Assembled on Gold Nanoparticles", Journal of Dispersion Science and Technology, 2014 More

Department Related Publications

  • Abd El Shafey Ibrahim Ahmed Ibrahim, "Macroscopic N-halamine biocidal polymeric beads", لايوجد, 2010 More
  • Wael Salah AbdelHalim, "Spin quenching of Mn in complexes and CO binding with Mn deposited on MgO and CaO supports: DFT calculations", Wiley, 2012 More
  • Walaa Helmy Fahmy Sheweny, "Synthesis, Characterization, DFT Modeling and Antimicrobial Studies on the Ti(IV), Y(III) and Ce(IV) Ofloxacin Solid Complexes", Printed in the Republic of Korea, 2013 More
  • Walaa Helmy Fahmy Sheweny, "SYNTHESIS, SPECTROSCOPIC, THERMAL AND BIOLOGICAL ACTIVITY INVESTIGATION OF NEW Y(ΙΙΙ) AND Pd(ΙΙ) NORFLOXACIN COMPLEXES", The Journal of the Argentine Chemical Society, 2010 More
  • Wael Salah AbdelHalim, "Characterization of van der Waals interaction potentialsD4h andTd configurations of He4", Wiley, 2000 More
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