The current work investigates the effects of drilling parameters on hole quality, including delamination and circularity, produced in hybrid composite materials consisting of neat glass fibre (NG) and hybrid glass fibre/Al-wire mesh in two distinct sequences, the first one being with Al-mesh in the outermost layers (AG) and the other with Al-mesh in the central layer (GA). The operation's process parameters are feed rate (F = 20, 40, and 60 mm/min), spindle speed (N = 1000, 2000, and 3000 rpm), and drill point angle (Ɵ = 90°, 120°, and 135°). Taguchi's L9 orthogonal array is used for the study. The optimal levels and effects of the process parameters were determined. Gray relational analysis (GRA) was employed to examine the complicated interactions influencing the results and ANOVA was used to evaluate the influence of process parameters. The results indicated that for all specimens, push-out delamination was more severe than peel-up. Circularity is minimized by using N = 3000 rpm, F = 20 mm/min, and Ɵ = 90°. At speed (N) of 3000 rpm circularity reduces by 83.5% and 76.5% compared to 1000 or 2000 rpm, respectively. Compared to other specimens, AG-specimen produced minimal delamination and circularity by an average of 6% and17.38%. The results of the confirmation test and regression model provide good agreement between the experimental and predicted results.