Impact of Ki 67 and Progesterone receptor status on the outcome of metastatic breast cancer patients treated with cyclin dependant kinase inhibitors

Faculty Medicine Year: 2024
Type of Publication: ZU Hosted Pages:
Authors:
Journal: African Journal of Biological Sciences African Society of Sustainable Development Volume:
Keywords : Impact , , , , Progesterone receptor status , , outcome of metastatic    
Abstract:
Abstract: Background: Breast cancer is the most common malignancy in females worldwide and is the second cause of cancer related mortality after lung cancer. Outcome of treatment of metastatic breast cancer is still controverse , up till now no clear data about effect of ki67 an PR status on treatment outcome. we aimed to determine the prognostic and predictive value of Ki67 and PR status among metastatic breast cancer patients on CDK4\6 inhibitor treatment. Patients and Methods: This observational prospective cohort study was conducted on 50 female patients with hormone- receptor-positive (HR+) and human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer (BC) from January 2022 till May 2024 with median follow up period 19.88 months (10.89- 28.09), treated and followed up at the Department of Medical Oncology, faculty of medicine, Zagazig University. Ki67 and progesterone receptor status were assessed by immunohistochemistry in primary tumor samples before starting the treatment. Results: Considering biobsy from primary tumour, IDC was the commonest pathological type (90.0%), Grade II was the commonest (64.0%) followed by Grade III (28.5%), ER positive was the commonest (93.0%), PR ≥ 20 % was (60.0%), Ki67 ≥ 14 % was (62.0%), The biobsy from metastatic site showed that, all the studied group were ER positive (100%), PR ≥ 20 % was (62%) and ki67 Low (< 0.001). Conclusion: Outcome of treatment of metastatic breast cancer is still controverse , Ki-67 and progesterone receptor status may be reliable predictors of response to CDK4/6 inhibitors in metastatic breast cancer, highlighting the need for further research to identify robust biomarkers. Alternative predictive biomarkers and patient stratification strategies are therefore crucial for optimizing treatment selection and improving outcomes.
   
     
 
       

Author Related Publications

  • Heba Fekry Abdel Majid Taha, "Combined Ezrin overexpression and E-cadherin downregulation as predictors of invasiveness, higher incidence of metastases, progression and poor prognosis in patients with cervical cancer", Egyptian Journal of Pathology, 2018 More
  • Heba Fekry Abdel Majid Taha, "The Value of FAK and SLUG Expression in Patients with Breast Carcinoma and Relation of Their Expression to Clinicopathological and Prognostic Parameters", Copyright © 2018, SciTechnol, 2018 More
  • Heba Fekry Abdel Majid Taha, "Prognostic and Clinic-Pathological Significances of SCF and COX-2 Expression in Inflammatory and Malignant Prostatic Lesions", springer, 2018 More
  • Heba Fekry Abdel Majid Taha, "Concordance between ER, PR, HER-2 neu Receptors Before and after Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer", Hellenic Society of Medical Oncology., 2020 More
  • Heba Fekry Abdel Majid Taha, "Clinical, pathological and prognostic implications of USP22, SIRT1 and Ecadherin expression in papillary thyroid cancer (PTC) and adjacent non-neoplastic tissue", BMC,Surgical and Experimental Pathology, 2019 More

Department Related Publications

  • Rasha Mohamed Mostafa Hagag, "Impact of Prognostic Nutritional Index and Systemic Immune-Inflammation Index on the Clinical Outcome of Patients with Advanced Hepatocellular Carcinoma Treated with Sorafenib", Zagazig University Medical Journal, 2022 More
  • Rasha Mohamed Mostafa Hagag, "Diagnosis of Sepsis among Adult Patients with AML Using Scd14", Ain Shams University, Faculty of Medicine, Pan Arab League of Continuous Medical Education, 2021 More
  • Rasha Mohamed Mostafa Hagag, "Prognostic Impact of microRNAs (miR-155, miR-10a, let-7a) on the Outcome of Adult Patients with Acute Myeloid Leukemia.", Zagazig University, Faculty of Medicine, 2021 More
  • Shereen Mostafa Saleh Elshorbagy, "Prognostic Roles of ZNF703 and SMAD4 Expression in Patients with Papillary Thyroid Cancer and Association with Nodal Metastasis", pubmed, 2022 More
  • Shereen Mostafa Saleh Elshorbagy, "RNA-binding proteins RBM-HuR, RBM3 and PODXL expression in urothelial carcinoma of the urinary bladder. Prognostic and clinical implications", PMID: 35079236, 2022 More
Tweet