Zagazig University Digital Repository
Home
Thesis & Publications
All Contents
Publications
Thesis
Graduation Projects
Research Area
Research Area Reports
Search by Research Area
Universities Thesis
ACADEMIC Links
ACADEMIC RESEARCH
Zagazig University Authors
Africa Research Statistics
Google Scholar
Research Gate
Researcher ID
CrossRef
Impact of Ki 67 and Progesterone receptor status on the outcome of metastatic breast cancer patients treated with cyclin dependant kinase inhibitors
Faculty
Medicine
Year:
2024
Type of Publication:
ZU Hosted
Pages:
Authors:
Heba Fekry Abdel Majid Taha
Staff Zu Site
Abstract In Staff Site
Journal:
African Journal of Biological Sciences African Society of Sustainable Development
Volume:
Keywords :
Impact , , , , Progesterone receptor status , , outcome of metastatic
Abstract:
Abstract: Background: Breast cancer is the most common malignancy in females worldwide and is the second cause of cancer related mortality after lung cancer. Outcome of treatment of metastatic breast cancer is still controverse , up till now no clear data about effect of ki67 an PR status on treatment outcome. we aimed to determine the prognostic and predictive value of Ki67 and PR status among metastatic breast cancer patients on CDK4\6 inhibitor treatment. Patients and Methods: This observational prospective cohort study was conducted on 50 female patients with hormone- receptor-positive (HR+) and human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer (BC) from January 2022 till May 2024 with median follow up period 19.88 months (10.89- 28.09), treated and followed up at the Department of Medical Oncology, faculty of medicine, Zagazig University. Ki67 and progesterone receptor status were assessed by immunohistochemistry in primary tumor samples before starting the treatment. Results: Considering biobsy from primary tumour, IDC was the commonest pathological type (90.0%), Grade II was the commonest (64.0%) followed by Grade III (28.5%), ER positive was the commonest (93.0%), PR ≥ 20 % was (60.0%), Ki67 ≥ 14 % was (62.0%), The biobsy from metastatic site showed that, all the studied group were ER positive (100%), PR ≥ 20 % was (62%) and ki67 Low (< 0.001). Conclusion: Outcome of treatment of metastatic breast cancer is still controverse , Ki-67 and progesterone receptor status may be reliable predictors of response to CDK4/6 inhibitors in metastatic breast cancer, highlighting the need for further research to identify robust biomarkers. Alternative predictive biomarkers and patient stratification strategies are therefore crucial for optimizing treatment selection and improving outcomes.
Author Related Publications
Heba Fekry Abdel Majid Taha, "Combined Ezrin overexpression and E-cadherin downregulation as predictors of invasiveness, higher incidence of metastases, progression and poor prognosis in patients with cervical cancer", Egyptian Journal of Pathology, 2018
More
Heba Fekry Abdel Majid Taha, "The Value of FAK and SLUG Expression in Patients with Breast Carcinoma and Relation of Their Expression to Clinicopathological and Prognostic Parameters", Copyright © 2018, SciTechnol, 2018
More
Heba Fekry Abdel Majid Taha, "Prognostic and Clinic-Pathological Significances of SCF and COX-2 Expression in Inflammatory and Malignant Prostatic Lesions", springer, 2018
More
Heba Fekry Abdel Majid Taha, "Concordance between ER, PR, HER-2 neu Receptors Before and after Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer", Hellenic Society of Medical Oncology., 2020
More
Heba Fekry Abdel Majid Taha, "Clinical, pathological and prognostic implications of USP22, SIRT1 and Ecadherin expression in papillary thyroid cancer (PTC) and adjacent non-neoplastic tissue", BMC,Surgical and Experimental Pathology, 2019
More
Department Related Publications
Rasha Mohamed Mostafa Hagag, "Impact of Prognostic Nutritional Index and Systemic Immune-Inflammation Index on the Clinical Outcome of Patients with Advanced Hepatocellular Carcinoma Treated with Sorafenib", Zagazig University Medical Journal, 2022
More
Rasha Mohamed Mostafa Hagag, "Diagnosis of Sepsis among Adult Patients with AML Using Scd14", Ain Shams University, Faculty of Medicine, Pan Arab League of Continuous Medical Education, 2021
More
Rasha Mohamed Mostafa Hagag, "Prognostic Impact of microRNAs (miR-155, miR-10a, let-7a) on the Outcome of Adult Patients with Acute Myeloid Leukemia.", Zagazig University, Faculty of Medicine, 2021
More
Shereen Mostafa Saleh Elshorbagy, "Prognostic Roles of ZNF703 and SMAD4 Expression in Patients with Papillary Thyroid Cancer and Association with Nodal Metastasis", pubmed, 2022
More
Shereen Mostafa Saleh Elshorbagy, "RNA-binding proteins RBM-HuR, RBM3 and PODXL expression in urothelial carcinoma of the urinary bladder. Prognostic and clinical implications", PMID: 35079236, 2022
More
جامعة المنصورة
جامعة الاسكندرية
جامعة القاهرة
جامعة سوهاج
جامعة الفيوم
جامعة بنها
جامعة دمياط
جامعة بورسعيد
جامعة حلوان
جامعة السويس
شراقوة
جامعة المنيا
جامعة دمنهور
جامعة المنوفية
جامعة أسوان
جامعة جنوب الوادى
جامعة قناة السويس
جامعة عين شمس
جامعة أسيوط
جامعة كفر الشيخ
جامعة السادات
جامعة طنطا
جامعة بنى سويف