The Neoproterozoic granitic rocks of Mount Abu Kibash and Tulayah in the central Eastern Desert of Egypt are of geodynamic interest and provide us with important information about the evolution and growth of the northern part of the Arabian–Nubian Shield (ANS) continental crust. They are primarily composed of granodiorites and syenogranites based on new field, mineralogical, and geochemical analyses. The granodiorites are marked by an enrichment of LILEs such as Sr, K, Rb, Ba compared to HFSEs like Nb, Ta, Ti and show a higher concentration of LREEs relative to HREEs. This composition suggests a subduction-related setting and aligns with the characteristics of subducted I-type granites in the ANS. Chemistry of the analyzed primary amphiboles in the investigated granodiorites support a calc-alkaline nature, mixed source and subduction-related setting. The granodiorites represent an early magmatic phase in this setting, likely formed from a mix of mantle-derived mafic magmas and lower crust material, with subsequent fractional crystallization. On the other hand, syenogranites exhibit high SiO2 (72.02–74.02 wt%), total alkali (7.82–8.01 wt%), and Al2O3 (13.79–14.25 wt%) levels, suggesting their derivation from peraluminous (A/CNK > 1) parental magmas. Their REE-normalized patterns are flat with a pronounced negative Eu anomaly, typical of post-collisional A2-type granites worldwide. These rocks originated from the partial melting of a juvenile lower crustal source (tonalite) in a post-collisional setting, driven by lithospheric delamination that facilitated mantle upwelling and underplating to the lower crust. Interaction between the upwelled mantle and lower crust led to fertilization (enrichment with HFSE and alkalis) of the lithosphere before partial melting. Fractional crystallization coupled with less considerable crustal assimilation are the main magmatic processes during the evolution of these rocks. The transition from subduction to post-collisional setting was accompanied by crustal uplifting, thickening and extensional collapse of ANS continental crust that caused emplacement of large masses of A-type granites in the northern ANS.