In the present study, the effects of corn germ meal (CGM) and bile acids (BA) inclusion in Japanese quail diet on the productive and reproductive performance, egg quality, and serum biochemical parameters were evaluated. Six wk old, 480 Japanese quail birds were randomly divided into 6 groups (60 hens and 20 males / group) with 4 replicates / group. CGM was incorporated at 0, 10 and 20 % of diet for groups (G1, G2, and G3), while G4, G5 and G6 had the same levels of CGM with BA addition (500 g/ton feed). The egg production (EP), egg mass (EM) and feed intake (FI) were significantly reduced (P < 0.05) in response to CGM feeding which was clear with the 20 %. CGM at 10% inclusion enhanced the feed conversion ratio (FCR), while incorporation at 20% deteriorated (P < 0.05) it compared to the control group. Addition of BA to the CGM-containing diets reduced the FI, improved FCR, and ameliorated the negative effects on EP, EM and FCR in the CGM fed birds. Feeding on 10% CGM single or combined with BA increased fertility %, chick's weight after hatching and reduced embryonic death. Serum concentrations of triglyceride and low-density lipoprotein (LDL) were significantly increased (P < 0.05) with CGM inclusion. Dietary CGM inclusion without or with BA was associated with higher levels of serum total cholesterol and low-density lipoprotein when compared to their control groups. BA addition to the CGM containing diets significantly reduced the alanine transaminase (ALT) activity (P ˂ 0.05) compared to their corresponding groups fed BA free diets especially those received the 10% CGM. Birds fed on 10% CGM supplemented with BA showed the highest economic efficiency values. In conclusion, CGM inclusion at 10% with BA supplementation could be used as alternative ingredient in the Japanese quail layer diet without compromising their productive performance.