Bioremediation is an ingenious and promising method pertinent for recuperating and removing toxic metals in polluted water and lands. Arsenic (As) contamination is a crucial matter worldwide as its supersaturation is gradually intensifying in our environment because of natural and anthropogenic exertion. Microorganisms have a pivotal role in the bioremediation of various arsenic species. Microorganisms can presumably decrease arsenic by employing genetic engineering. By introducing innovative catabolic pathways with the help of different computational tools or by engineering the prevailing metabolic pathways, the limitations likely to crop up in bioremediation can be suppressed. This review accentuates the significance of microbes for the bioremediation of arsenic, and along with that, it scrutinizes the disadvantages and incapability of native and engineered microbes for bioremediation. In addition, arsenic bioremediation employing genetically modified bacteria is more ecologically friendly. It has fewer health hazards than physiochemical-based methods such as coagulation or filtration sedimentation, electrodialysis or osmosis, chemical precipitations, and adsorptions.